Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in the gynecological field and considering the importance of mental health, this study was designed to compare the prevalence of depression among women with PCOS and the control group. Materials and Methods: The present cross sectional study was conducted as a case control research, which included 73 cases of PCOS and 116 healthy women (controls). Data was gathered in 2 sections, i. e.1. participant characteristics and 2. an assessment of their depression levels using the Beck questionnaire. Reproductive aged women (15-45 years old) completed the questionnaire. Statistics analysis was done using SPSS version 19. Results: Mean scores of depression was 11.8±9.6  and 8.6±8.2 in the case and control groups respectively, with a statistically significant difference (P<0.01). Sixteen (21%) patients and 10 (8%) women controls had moderate to severe depression, levels, both significantly higher in cases than in controls (P<0.01). Conclusion: Considering the higher prevalence of depression in PCOS patients, compared to controls, early screening and counseling are recommended to provide appropriate care for these affected women.