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:: Volume 4, Issue 3 (9-2002) ::
2002, 4(3): 165-168 Back to browse issues page
Association between vitiligo and thyroid dysfunction
SH ManiGhalam , M HajeAbdolhamid, P Tosi, A AmirJavanbakht, N Sadat
Abstract:   (24380 Views)
Introduction: Considering existing controversies regarding an association between vitiligo and thyroid dysfunction, this study was conducted among patients afflicted with vitiligo and a control group in Tehran-2001. Material and methods: This was an analytical case-control study carried out on 30 individuals of whom those whose disease had begun, at least one year ago, were registered as cases and some information such as age, sex, duration and rate of skin involvement, also symptoms and signs of thyroid disease was documented. Thirty individuals referring to dermatology clinics for complications other than vitiligo were considered as the control group (age and sex were matched with patient's group). Both patients and control groups were assessed for T3, T4, TSH, T3RU and FTI was calculated. Then hypo-hyper- and euthyroids were determined based on FTI and T3 (For T3 Hyperthyroidism) levels and findings were analyzed by statistical methods (T test, chi-square, fisher test). Results: Each study group consisted of 30 people (73% female, 27% male) with a mean age of 31.7±11.4 in patient group and 31.7±11.2 in control group. Duration of disease was 8.3 ± 2.4 years and rate of skin involvement was 22.4 ± 12.5 % only one of them showing signs and symptoms of hyperthyroidism. T3 levels were 1.5 ± 0.54 ng/dl in the patient group and 1.4 ± 0.47 ng/ dl in control group. T4 level was 8.8 ± 2.8 in the patient group and 7.53 ± 0.32 µg/dl in the control group. TSH level was 0.75 ± 0.5 in the patient group and 0.81 ± 0.5 µ unit /ml in the control group. T3RU in the patient group was 31.2 ± 3.2 % and in control group was 29.8 ± 4.2% and FTI 2.8 ± 0.97 in patient group and 2.5 ± 0.55 in the control group. Based on FTI, there are 16.6% thyroid dysfunctions among patients with vitiligo consisting of 10% hyperthyroidism and 6.6% hyperthyroidism. There was no T3 hyperthyroidism, based on T3 levels. In the control group there were no cases of thyroid dysfunction. Conclusion: This study demonstrated that vitiligo seems to have an association with thyroid dysfunctions (hypo & hyperthyroidism). To confirm this, further studies with larger sample sizes and complementary lab tests are recommended. In future, patients with vitiligo will be evaluated for thyroid dysfunctions in a periodical manner and if necessary be treated to prevent occurence of complications of thyroid disease.
Keywords: vitiligo – hyperthyroidism – Hypothyroidism
Full-Text [PDF 226 kb]   (7266 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/22
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ManiGhalam S, HajeAbdolhamid M, Tosi P, AmirJavanbakht A, Sadat N. Association between vitiligo and thyroid dysfunction. Iranian Journal of Endocrinology and Metabolism. 2002; 4 (3) :165-168
URL: http://ijem.sbmu.ac.ir/article-1-198-en.html


Volume 4, Issue 3 (9-2002) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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