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:: Volume 16, Issue 1 (5-2014) ::
2014, 16(1): 47-56 Back to browse issues page
A Review of Models of Hypothyroidism in the Rat: Comparison of the Thyroid Function in Rats and Humans
Sajad Jeddi , Asghar Ghasemi Dr. , Saleh Zahediasl Dr
Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Ghasemi@endocrine.ac.ir
Abstract:   (13197 Views)

Introduction: Human subjects can not always used as models for studying disease by researchers because of the potential risks for human health, and in addition, control of interfering factors is not easy in these subjects. Animal biology, physiology, anatomy, biochemistry, pharmacology, and genetics are very similar to humans. Animals are suitable models for research, as their functional body system is similar to humans and is easily manipulated. Most of our current knowledge in medical sciences is obtained from animal studies, among which, rats and mice are mostly used for the their shorter lifespans, which creates the possibility of producing many generations and studying total lifespan. The thyroid plays pivotal role in the body and is vital for normal function of almost all tissues throughout life. Decreased secretion of thyroid hormones from the thyroid gland (hypothyroidism) is a prevalent disorder and as a result animal models of hypothyroidism are often very important for research purposes. Thyroidectomy, genetic manipulation, and using anti-thyroid drugs are the most important ways to induce hypothyroidism in animals. The aim of this study was to review and evaluate different models for induction of hypothyroidism in rat, and in addition to compare the characteristics of rat and human thyroid glands. Conclusions: Anti-thyroid drugs could be used as cheap, available, and simple methods for inducing hypo­thyroidism, although they may also affect the function of other organs.

Keywords: Animal models, Hypothyroidism, Rat, Propylthiouracil
Full-Text [PDF 324 kb]   (2239 Downloads)    
Type of Study: Review | Subject: Endocrinology
Received: 2013/09/1 | Accepted: 2014/01/11 | Published: 2014/05/20
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Jeddi S, Ghasemi A, Zahediasl S. A Review of Models of Hypothyroidism in the Rat: Comparison of the Thyroid Function in Rats and Humans. Iranian Journal of Endocrinology and Metabolism. 2014; 16 (1) :47-56
URL: http://ijem.sbmu.ac.ir/article-1-1594-en.html


Volume 16, Issue 1 (5-2014) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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