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:: Volume 16, Issue 1 (5-2014) ::
2014, 16(1): 26-32 Back to browse issues page
Effect of a Period of Endurance Training on Serum Il-8 Concentration and Tumor Volume in Breast Cancer Bearing Mice
Hamid Agha-Alinejad Dr , Shiva Haftchenari, Hasan Matin Homaee Dr
Tarbiat Modares University , halinejad@modares.ac.ir
Abstract:   (5176 Views)

Introduction: Exercise training, an adjuvant therapy has a prophylactic effect on improvement of breast cancer. The purpose of this study was investigating the effect of endurance training on serum IL-8 concentration and tumor volume in breast cancer bearing mice. Materials and Methods: Forty female BALB/c mice (4 to 5 week years old, average 17 g weight) were randomly assigned into four groups: 1) exercise-tumor-exercise (ETE), 2) exercise-tumor-rest (ETR), 3) rest-tumor-exercise (RTE) and 4) rest-tumor-rest (RTR). For tumorigenesis, MC4-L2 cell lines were used. Endurance training was performed for 8 weeks before inducing tumor in which training was initiated with 50% VO2max and reached 75% VO2max in the 8th week. Endurance training was performed with the intensity of 50 to 65% VO2max for 6 weeks after tumor induction. After training, serum IL-8 concentration was measured by ELISA. Data were analyzed by one-way ANOVA and Pearson correlation. Results: There were significant differences in serum IL-8 concentration and tumor volume among the groups (P=0.0001). Significant differences were between training groups after tumor induction with other groups. In addition, significant correlations were observed between serum IL-8 concentration and tumor volume among the groups (P>0.05). Conclusions: Endurance training with moderate intensity reduces tumor volume. IL-8 is involved in angiogenesis and tumor growth and the decreased level of IL-8 is one reason for the reduced tumor volume. Due to reduction of the level of this cytokine in groups doing exercise after malignancy, endurance training in addition to a prophylactic role is presumed to have adjuvant therapeutic effects on estrogen-receptor dependent tumors.

Keywords: Breast Cancer, Endurance Training, Tumor Volume, IL-8
Full-Text [PDF 285 kb]   (1796 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2013/07/21 | Accepted: 2014/02/26 | Published: 2014/05/20
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Agha-Alinejad H, Haftchenari S, Matin Homaee H. Effect of a Period of Endurance Training on Serum Il-8 Concentration and Tumor Volume in Breast Cancer Bearing Mice. Iranian Journal of Endocrinology and Metabolism. 2014; 16 (1) :26-32
URL: http://ijem.sbmu.ac.ir/article-1-1577-en.html


Volume 16, Issue 1 (5-2014) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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