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:: Volume 15, Issue 5 (2-2014) ::
2014, 15(5): 443-449 Back to browse issues page
Association of LXRβ rs17373080 Polymorphism with Obesity and Obesity-Related Phenotypes in an Iranian population
Hassan Rooki Dr , Majid Ghayour-Mobarhan Dr., Mohammad-Reza Zali Dr.
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , rookihassan@gmail.com
Abstract:   (5343 Views)

Introduction: Liver X receptor Beta (NR1H3) has a pivotal role in carbohydrate and lipid metabolism and is located in an obesity susceptibility region, and genetic variations in it may play a role in etiology of human obesity. This study aims to assess the association of the LXRβ rs17373080 polymorphism with obesity and related traits. Materials and Methods: A total of 435 unrelated subjects, including 160 obese, 201 overweight and 74 controls randomly selected from Mashhad city, were enrolled in the present case-control study. The anthropometric and biochemical parameters were measured and DNA samples were genotyped by the TaqMan assay. Results: Allelic and genotypic frequencies showed no significant associations with obesity and related traits, even after age and gender adjustment. By logistic regression using a dominant model, the odds ratios for the obesity were: 0.85 (0.46-1.57) for genotype CG and 1.14 (0.48-2.69) for genotype GG, compared with the genotype CC as a reference. The allelic frequency of the LXRβ gene variant in whole population and also in three BMI groups was in the Hardy-Weinberg equilibrium. Conclusions: This study revealed no association between LXRβ rs17373080 polymorphism and the risk of obesity in an Iranian population, suggesting this SNP is not a major contributor to risk of obesity.

 

Keywords: Obesity, Liver X receptor-β, rs17373080, BMI, Polymorphism
Full-Text [PDF 286 kb]   (2167 Downloads)    
Type of Study: Original | Subject: Genetic
Received: 2013/06/13 | Accepted: 2013/08/18 | Published: 2014/01/29
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Rooki H, Ghayour-Mobarhan M, Zali M. Association of LXRβ rs17373080 Polymorphism with Obesity and Obesity-Related Phenotypes in an Iranian population. Iranian Journal of Endocrinology and Metabolism. 2014; 15 (5) :443-449
URL: http://ijem.sbmu.ac.ir/article-1-1554-en.html


Volume 15, Issue 5 (2-2014) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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