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:: Volume 14, Issue 6 (3-2013) ::
2013, 14(6): 580-585 Back to browse issues page
Oxymetholone Induced Complications, on Testosterone, LH and FSH Hormone Levels among Male Rat Progeny Whose Mothers were Treated by Oxymethalone During Pregnancy and Lactation
Vahid Hemayatkhah Dr , Samaneh Zolghadri, Mona Khajehei, Hossein Kargar
University Jahrom , dr.hemayatkhah@yahoo.com
Abstract:   (6854 Views)
Introduction: Oxymetholone is an active nutritional anabolic steroid – androgenic which can result in some abnormalities such as lung cancer, ovarian cycle irregularity and liver cancer. The aim of this study is to investigate oxymetholone induced complications in levels of testosterone, LH, FSH hormones in mature progeny male rats, whose mothers were treated by oxymetholone during different pregnancy and lactation periods. Materials and Methods: In this study we used fifty six female rats and fourteen male rats aged 110-120 days, weighing were approximately 200±20g. The animals were divided into groups including control, solvent 1 (pregnancy- 21 days), solvent 2 (pregnancy- lactation- 42days) solvent 3 (lactation – 21 days), experimental 1 (pregnancy 21 days) experimental 2 (pregnancy- lactation- 42 days), and experimental 3 (lactation-21 days). Solvent groups used DMSO with 99.5% concentration and experimental groups used oxymetholone with 10 mg/kg concentration by intra peritoneum method. Hormone concentrations were measured by the radio immunoassay method. Results: The rate of LH indicated significant decrease in experimental groups of pregnancy-lactation and lactation. FSH levels in the experimental groups of pregnancy-lactation and lactation and also testosterone in the experimental groups of pregnancy-lactation decreased compared to the control group. Conclusion: Oxymetholone in these doses most probably results in decreased LH, FSH and testosterone concentrations, leading to disturbances in the reproductive system of wistar.
Keywords: Oxymetholone, Testosterone, FSH, LH, Rat
Full-Text [PDF 267 kb]   (2802 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2012/04/8 | Accepted: 2013/03/6 | Published: 2013/03/6
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hemayatkhah V, zolghadri S, khajehei M, kargar H. Oxymetholone Induced Complications, on Testosterone, LH and FSH Hormone Levels among Male Rat Progeny Whose Mothers were Treated by Oxymethalone During Pregnancy and Lactation . Iranian Journal of Endocrinology and Metabolism. 2013; 14 (6) :580-585
URL: http://ijem.sbmu.ac.ir/article-1-1366-en.html


Volume 14, Issue 6 (3-2013) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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