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:: Volume 7, Issue 2 (6-2005) ::
2005, 7(2): 157-165 Back to browse issues page
The effect of L-carnitine supplement on lipidemic and glycemic profile in patients with type II diabetes mellitus
R Shakerhosseini , A Rahbar , N Saadat , F Pordal , A Taleban , B Golestan
Abstract:   (25398 Views)
Objective: We designed this study to investigate the effects of oral L-carnitine administration on fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and lipid parameters in patients with diabetes mellitus type II. Materials and methods: The effect of L-carnitine on FPG and lipid parameters was investigated in 22 male and 14 female type II diabetic patients, mean age±SD was 51.3±3.7 years. The patients were randomly divided into 2 groups (i.e.test and control groups). One gram of L-carnitine or placebo was given orally three times a day to the test and control groups respectively for a period of 12 weeks. Results: Fasting plasma glucose in the test group decreased significantly from 143±35 mg/dl to130±33 mg/dl (p=0.03), and a significant increase of triglycerides (TG) from 196±61 mg/dl to 233±116 mg/dL (p=0.05), of APO A1 from 94±20 mg/dL to103±23 mg/dl (p=0.02), of APO B100 from 98±18 mg/dL to108±22 mg/dl (p=0.02) after 12 weeks of treatment was observed. There were no significant changes in LDL-C, HDL-C, HbA1C or in total cholesterol (TC) between the two groups. Conclusion: L-carnitine significantly lowers fasting plasma glucose but increases fasting triglycerides in type II diabetic patients.
Keywords: L-carnitine, Diabetes, Apolipoprotein
Full-Text [PDF 294 kb]   (2517 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/16
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Shakerhosseini R, Rahbar A, Saadat N, Pordal F, Taleban A, Golestan B. The effect of L-carnitine supplement on lipidemic and glycemic profile in patients with type II diabetes mellitus. Iranian Journal of Endocrinology and Metabolism. 2005; 7 (2) :157-165
URL: http://ijem.sbmu.ac.ir/article-1-123-en.html


Volume 7, Issue 2 (6-2005) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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