[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 13, Issue 6 (9-2011) ::
2011, 13(6): 673-680 Back to browse issues page
The Association Study of The E23k Kcnj11 Variant with Progression of Type 2 Diabetes Among Obese Individuals in A Population in the North of Iran
Malaeke Ghasemi, Razeih Habibipour, Parvaneh Keshavarz Kiasaraei Dr
Celluar and Mulecular Research Center of Guilan University of Medical Science , parvan1372@yahoo.com
Abstract:   (11702 Views)
Introduction: Obesity is a polygenic disorder and a risk factor for type 2 diabetes (T2D). The E23K variant of KCNJ11gene is responsible for reduction in electrical excitability of pancreatic β- cells contributing to the impairment of insulin secretion, a common dysfunction in obese T2D individuals due to increase in KATP channel activity in the presence of LC-CoAs. Several studies have reported the association of the E23K variant with T2D and obesity in different populations. The aim of this study was to investigate the association of the E23K variant with progression of T2D among obese individuals in a population of Guilan in the north of Iran. Materials and Methods: Two case-control association studies were performed using 210 T2D and non-diabetic-obese individuals as well as 536 T2D and non-diabetic subjects without obesity. MGB TaqMan assay by Real time PCR (ABI 7300) was applied for genotyping of samples. Results: According to allele frequency, there were no significant differences between diabetic and non-diabetic obese subjects or between non-obese individuals with and without T2D. With genotype frequency comparison, in obese subjects there was significant difference between diabetic and non diabetic individuals in a recessive genetic model [OR=4.4 CI 95 %(0.98-19.96) P=0.024]. However, in non-obese individuals, there was no significant difference in diabetic and non diabetic subjects. Conclusion: This study reports that the E23K variant is associated with progression of T2D in obese individuals. More investigations in larger popula‌tions with insulin measurment are recommended.
Keywords: Type 2 diabetes, Obesity, polymorphism, E23K, Association study, KCNJ11
Full-Text [PDF 315 kb]   (1528 Downloads)    
Type of Study: Original | Subject: Genetic
Received: 2011/07/19 | Accepted: 2011/10/24 | Published: 2014/05/24
Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

ghasemi M, Habibipour R, Keshavarz Kiasaraei P. The Association Study of The E23k Kcnj11 Variant with Progression of Type 2 Diabetes Among Obese Individuals in A Population in the North of Iran. Iranian Journal of Endocrinology and Metabolism. 2011; 13 (6) :673-680
URL: http://ijem.sbmu.ac.ir/article-1-1201-en.html


Volume 13, Issue 6 (9-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 33 queries by YEKTAWEB 3877