:: Volume 13, Issue 4 (11-2011) ::
2011, 13(4): 398-405 Back to browse issues page
Folate and Vitamin B12 Intake and Risk of Squamous-cell Carcinoma of the Esophagus
B Hajizadeh, S Mirzaeian, B Rashidkhani Dr
Shahid Beheshti University of Medical Sciences , b_rashidkhani@sbmu.ac.ir
Abstract:   (26613 Views)

Introduction: Esophageal cancer is one of the most common cancers in Iran and has a high mortality rate. The aim of this study was to assess the association between folate and vitamin B12 intake and risk of squamous-cell carcinoma of the esophagus cancer. Materials and Methods: In this case-control study, cases (n=47) were patients diagnosed with squamous-cell carcinoma of the esophagus (SCCE) in main hospital Kurdistan and controls (matched with cases by age and sex) were patients with acute non-cancer diseases at the same hospitals (n=96). Demographic data and physical activity were collected using questionnaires. A semi-quantitative food frequency questionnaire used for nutritional information and folate and vitamin B12 intake were calculated with Nutritionst IV (N4). Results: Thirty eight percent of cases and 40% of controls were males. Mean age of cases and controls were 58±18 and 58±17 years respectively. Mean folate intake among cases was 152.1 μg/day, which was less than in the controls. After adjustment for confounders, folate intake was inversely related with SCCE (OR=0.03, 95% CI 0.00, 0.12). The association between vitamin B12 intake and SCCE was not significant (p=0.46). Conclusion: Folate intake was inversely related with SCCE: however, there was not a significant association between vitamin B12 intake and SCCE.

Keywords: Squamous-cell carcinoma, Esophagus, Folate, B12, Food intake
Full-Text [PDF 294 kb]   (2163 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2011/01/27 | Accepted: 2011/06/14


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Volume 13, Issue 4 (11-2011) Back to browse issues page