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:: Volume 13, Issue 4 (11-2011) ::
2011, 13(4): 354-360 Back to browse issues page
Effect of Folic Acid Supplementation on Indices of Glycemic Control, Insulin Resistance and Lipid Profile in Patients With Type 2 Diabetes Mellitus
Vahideh Aghamohammadi khiavi, Bahram Pourghassem Gargari Dr , Akbar Aliasgharzadeh Dr
School of Health &Nutrition, Nutritional Research Center, Tabriz University of Medical Sciences , bahrampg@yahoo.com
Abstract:   (37947 Views)

Introduction: This study was performed to determine the effects of supplementation of folate on indices of glycemic control, insulin resistance and lipid profile in in men with type 2 diabetes, under metformin (at least 1500mg daily) treatment. Materials and Methods: This was a double-blind randomized controlled clinical trial, in which 68 men with type 2 diabetes participated with written consents. Patients were randomly divided in two groups folic acid 5mg/day and placebo. All the patients received the tablets for 8 weeks. Anthropometric and nutrient intakes data were obtained from each patient, and baseline and 8th week fasting blood glucose, HbA1C, serum insulin, insulin resistance, serum total cholestrol, TG, LDL-C, HDL-C, serum folate and plasma homocysteine were measured. Results: Supplementation with folic acid led to 6.3 percent decrease in HbA1C (P=0.019), 9.5 percent decrease in fasting blood glucose (P=0.006), 15.1 percent decrease in serum insulin (P=0.028), 17.2 percent decrease in insulin resistance (P=0.043) and 20 percent decrease in plasma homocysteine (P<0.001), 18.4 percent increase in serum folate (P<0.001). No significant changes occurred in the placebo group (P>0.05).  Conclusion: A pharmacological dose of folic acid supplementation decreased plasma level of homocysteine and improved glycemic control, insulin resistance and folate levels, a finding which sugqests a safe and inexpensive therapy for lowering homocysteine and improving the overall management of diabetic patients.

Keywords: Folic acid, Type 2 diabetes, Glycemic control, Insulin resistance, Metformin
Full-Text [PDF 291 kb]   (3093 Downloads)    
Type of Study: Original | Subject: Nutrition
Received: 2010/11/15 | Accepted: 2011/07/2
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Aghamohammadi khiavi V, Pourghassem Gargari B, Aliasgharzadeh A. Effect of Folic Acid Supplementation on Indices of Glycemic Control, Insulin Resistance and Lipid Profile in Patients With Type 2 Diabetes Mellitus. Iranian Journal of Endocrinology and Metabolism. 2011; 13 (4) :354-360
URL: http://ijem.sbmu.ac.ir/article-1-1064-en.html


Volume 13, Issue 4 (11-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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