Abstract

Introduction: The aim of this study was to investigate the effect of broccoli sprout powder (BSP) on fasting serum glucose (FBS) and lipid profiles in type 2 diabetic patients. Materials and Methods: Sixty-three type 2 diabetic patients were randomized into three groups: 1)10g/d BSP, n=21, 2) 5g/d BSP, n=22 and 3) 5g/d placebo, n=20. Serum levels of FBS, total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C were measured before and 4 weeks after intervention. Results: After 4 weeks, broccoli sprouts powder induced a significant (13.5%) decrease in TG  concentration in group 1, as compared to controls (p<0.05). Higher mean concentration of HDL-C was observed after 4 weeks in group 1, compared to group 2 and controls (p<0.05). Atherogenic index of plasma was significantly, lower in group 1 as compared with other groups, after 4 weeks intervention (p<0.01). As compared to baseline, FBS and TC decreased significantly, 19.6% and 16.5% in group 1, and 12% and 12.5% in group 2, after 4 weeks. TC: HDL-C and LDL-C:HDL-C ratios significantly decreased, 12.3% and 10.6% in group 1 after 4 weeks (p<0.05). Conclusion: Administration of broccoli sprout powder had favorable effects on lipid profiles, in type 2 diabetic patients.