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:: Volume 13, Issue 1 (5-2011) ::
2011, 13(1): 74-81 Back to browse issues page
Effects of Lead Acetate, Endurance Training and Curcumin Supplementation on Heat Shock Protein Levels in Liver Tissue
Mojgan Memar Moghadam , Valiollah Dabidi roshan Dr, Mehdi Hedayati Dr
Abstract:   (29498 Views)

Introduction: Heat shock proteins act as guardians of cells. The stimulation of these proteins due to stress conditions that activates the cell protective mechanisms is essential. Materials and Methods: In this study, in order to assess the effects of lead, regular exercise endurance and HSP72 protein supplement Curcumin on the liver tissue, 48 mice were classified randomly into control groups 1) Base and 2) Sham and four experimental groups included 3) Lead, 4) Lead + endurance training, 5) Lead + Curcumin, 6) Lead + endurance training + Curcumin. Groups of 3 to 6 received 20 mg of lead groups 5 and 6 in addition to lead received 30 mg/kg curcumin for 8 weeks and 3 days intraperitoneally. Furthermore, groups 4 and 6 performed progressive running training sessions, 15 to 22 m/min, for 25 to 64 min, five times a week HSP72 level in homogenized liver tissue was measured by ELISA method. Data were analyzed by one way ANOVA test, P≤0.05. Results: HSP72 and malondialdehyde levels in the lead group were significantly higher than the other groups, while superoxide dismutase and total anti-oxidative capacity were less than other groups. In contrast, HSP72 and malondialdehyde in the curcumin, endurance training and the combination groups were significantly lower than the lead groups. Conclusion: These findings suggest that healthy lifestyle, including aerobic exercise and anti oxidant supplements may have beneficial effects in preventing oxidative damage caused by lead.

Keywords: Endurance Training, HSP72, Oxidative Damage, Anti oxidant, Lead
Full-Text [PDF 372 kb]   (2839 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2010/08/30
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Memar Moghadam M, Dabidi roshan V, Hedayati M. Effects of Lead Acetate, Endurance Training and Curcumin Supplementation on Heat Shock Protein Levels in Liver Tissue . Iranian Journal of Endocrinology and Metabolism. 2011; 13 (1) :74-81
URL: http://ijem.sbmu.ac.ir/article-1-1016-en.html


Volume 13, Issue 1 (5-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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