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Effects of Silymarin on Blood Glucose and Lipid Profile in Rats Treated with Isoprenaline
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M Sadeghi-Azar    , SS Talebi , E Shiri , S Shahidi , F Ramezani-Aliakbari |
| Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, & Neurophysiology Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, I.R. Iran , f.ramezani@umsha.ac.ir |
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Abstract: (31 Views) |
Introduction: Hyperlipidemia and hyperglycemia are major risk factors for the development of cardiovascular diseases. Silymarin is a natural antioxidant that has shown promising cardioprotective effects. This study aimed to evaluate the effects of Silymarin on blood glucose levels and lipid profiles in rats treated with Isoprenaline. Materials and Methods: Rats were randomly assigned to four groups (n = 5 per group): a control group; a Silymarin group (receiving 50 mg/kg Silymarin for 14 days); an Isoprenaline group (receiving 5 mg/kg Isoprenaline for 10 days); and an Isoprenaline + Silymarin group (receiving Isoprenaline and 50 mg/kg Silymarin for 14 days). On day 15, following 12 hours of fasting, blood samples were collected via the renal vein. Serum glucose concentrations and lipid profiles were measured. Results: The findings showed that Isoprenaline administration induced hyperglycemia and hyperlipidemia. Treatment with Silymarin significantly reduced blood glucose, triglyceride and cholesterol levels in rats receiving Isoprenaline. Additionally, rats treated with Silymarin alone exhibited a significant increase in triglycerides and a significant decrease in high‑density lipoprotein compared with the control group. Conclusion:The results of this study indicate that Silymarin is effective in improving Isoprenaline‑induced hyperglycemia and hyperlipidemia, likely through mechanisms involving enhanced antioxidant status. In addition, Silymarin may increases triglycerides and decreases high-density lipoprotein in untreated rats through the reduction of reactive oxygen species. |
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| Keywords: Isoprenaline, Silymarin, Hyperlipidemia, Hyperglycemia, Rat |
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Full-Text [PDF 627 kb]
(27 Downloads)
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Type of Study: Original |
Subject:
Cardiology
Received: 2025/11/25 | Accepted: 2026/02/7 | Published: 2026/04/30
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