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Vitamin D and Anti-thyroid Peroxidase Antibody: Tehran Thyroid Study
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FS Saeidian    , F Sarvghadi , A Amouzegar , L Mehran , S Mahdavi , Y Mehrabi , F Azizi , H Abdi |
| Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran , abdi@endocrine.ac.ir |
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Abstract: (391 Views) |
Introduction: Considering the inconsistent data on the relationship between vitamin D (VD) and autoimmune thyroid diseases, we aimed to investigate associations of VD with anti-thyroid peroxidase antibody (TPOAb). Materials and Methods: For this study, 695 subjects, including 369 women, were enrolled. TPOAb status was compared between different categories of VD deficiency (VDD), and correlations between TPOAb and VD were estimated. Multiple logistic regression analysis investigated the associations between VD status and TPOAb positivity. Results: The prevalence of VDD was 82%. There was no statistically significant difference in the prevalence of TPOAb positivity among different VD groups (p-value=0.18), a finding that did not change when TPOAb titer was considered a continuous variable. Multiple logistic regression analysis showed no significant relationships between VD status and TPOAb positivity. Regarding thyroid function, a weak negative correlation between 25(OH) D and TSH in men and a weak positive correlation between 25(OH) D and FT4 in women was demonstrated. Conclusion: Our study in a population with a high prevalence of VDD revealed no statistically significant associations between serum VD levels and either TPOAb levels or TPOAb positivity. |
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| Keywords: Vitamin D, Anti-thyroid peroxidase antibody, Thyroid autoimmunity |
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Full-Text [PDF 966 kb]
(320 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2024/10/8 | Accepted: 2024/11/4 | Published: 2024/02/29
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