fa پژوهشی Original Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is changed in the brain of the diabetic animal model. Materials and Methods: To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water (10%). The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Results: Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. Conclusion: The unchanged expression levels of IGF-I receptor and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue. Diabetes type II, Insulin Resistance, Brain, IGF binding protein I, IGF-I receptor 707 712 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-799-13&slc_lang=fa&sid=1 A. Parvaneh Tafreshi آزیتا پروانه تفرشی tafreshi@nigeb.ac.ir 4000319475328460011371 4000319475328460011371 Yes R Jalal راضیه جلال 4000319475328460011485 4000319475328460011485 No S Darvishalipour شمیلا درویش علی پور 4000319475328460011486 4000319475328460011486 No H Sepehri حوری سپهری 4000319475328460011487 4000319475328460011487 No K Adeli خسرو عادلی 4000319475328460011488 4000319475328460011488 No