fa ارتباط بین غلظت روی و لپتین سرم در زنان یائسه‌ی مبتلا به دیابت نوع 2 پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><font face="Arial"><strong>Abstract</strong></font></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Leptin, a hormone secreted by the adipocytes, plays a key role in a feedback loop that maintains energy balance by signaling the state of energy stores to the brain and by influencing the regulation of appetite and energy metabolism. Zinc (Zn) also plays<span dir="rtl"></span></font><span dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Lotus mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> </span><font face="Arial">an important role in appetite regulation. It has been shown that Zn deficiency decreases appetite and that Zn supplementation increases it. Our aim is to evaluate the relationship between serum Zn, and leptin in postmenopausal diabetic women. <u>Materials and Methods</u>: We studied 45 diabetic women and 45 healthy women (controls) with Body Mass Index (BMI) 25-30 kg/m2 and age 45-60 y. Serum leptin, serum zinc, Tumor Necrosis Factor-α (TNF-α), and Interleukin-6 (IL-6) were determined in diabetic and healthy groups. Comparisons were performed with the t test in diabetic and healthy groups. Linear regression was used to evaluate the relations among different variables in the two groups. <u>Results</u>: There was a non-significant, negative correlation between serum leptin and zinc in postmenopausal diabetic women (r=-0. 14), and, a non-significant, positive correlation between serum leptin and zinc in postmenopausal healthy women (r= 0. 10). TNF-α and IL-6 have no significant effects on the relationship between serum zinc and leptin in postmenopausal diabetic and healthy women. <u>Conclusion</u>: There was no significant relationship between serum leptin and zinc in postmenopausal diabetic women. The pathophysiological pathways by which zinc and leptin regulate energy intake and appetite and the detailed mechanism between them need to be further clarified by future studies. </font></strong></p> لپتین، روی، دیابت نوع2، زنان یائسه Leptin, Zn, Type 2 diabetes mellitus, Postmenopausal women 656 660 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-799-6&slc_lang=fa&sid=1 M.M Taghdir مریم تقدیر 4000319475328460011364 4000319475328460011364 No A Djalali محمود جلالی jalalikh@sina.tums.ac.ir 4000319475328460011464 4000319475328460011464 Yes A. Djazayeri سیدابوالقاسم جزایری 4000319475328460011465 4000319475328460011465 No M Ashourpour مهکامه عاشورپور 4000319475328460011466 4000319475328460011466 No M Sepandi مجتبی سپندی 4000319475328460011467 4000319475328460011467 No