fa اثر سیر بر آسیب‏های بیضه‏ای ناشی از دیابت شیرین در موش‌های صحرایی نر پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial">Abstract</font></strong></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Diabetes mellitus is associated with histologic alterations of the testis. In the present study, we aimed to investigate both preventive and protective effects of garlic juice on testicular damage in male rats with streptozotocin (STZ)-induced diabetes. <u>Materials and Methods</u>: Forty male wistar rats were divided into 5 groups: 1) Group normal (N), 2) Group Normal+Garlic (N+G), 3) Diabetic (D) received STZ, 60mg/kg BW /i.p., 4) Group diabetic+garlic before (D+Gb) received garlic juice for 3 weeks before STZ injection and for 3 weeks after, and 5) Group diabetic+garlic after (D+Ga) three days after STZ injection, received garlic juice for 3 weeks. Garlic juice was given by gavage (1ml/100g BW). Testicular damage was examined using hematoxylin and eosin staining. <u>Results</u>: Diabetic rats showed a significant reduction in seminiferous tubule diameter and the number of germ cells. Garlic significantly attenuated the diabetes-induced morphological changes and the decrease in germ cells. The diabetic group receiving garlic before STZ injection (D+Gb) showed more amelioration in complications than that receiving it after STZ injection. <u>Conclusion</u>: In this study, for the first time, we showed that administration of garlic juice could play both preventive and therapeutic roles in testicular damage in male diabetic rats.</font></strong></p> سیر، آسیب‌های بیضه‌ای، دیابت، موش صحرایی نر Garlic, Testicular damage, Diabetes, Male rat 443 453 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-4-103&slc_lang=fa&sid=1 A Abdolahnejad اکرم عبداله نژاد 4000319475328460011350 4000319475328460011350 No A Gol علی گل agol@mail.uk.ac.ir 4000319475328460011415 4000319475328460011415 Yes Sh Dabiri شهریار دبیری 4000319475328460011416 4000319475328460011416 No A Javadi عبدالرضا جوادی 4000319475328460011417 4000319475328460011417 No