fa اثر مکمل اسیدلینولئیک مزدوج بر آپوپروتئین B و مالون دی‌آلدئید در بیماران دیابت نوع 2 پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial">Abstract</font></strong></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Some animal studies have suggested that Conjugated Linoleic acid (CLA) supplementation may have therapeutic potential with respect to lipid metabolism, considered to be the most important cardiovascular disease (CVD) related risk factor, associated with type 2 diabetes mellitus (T2DM). However, results from human studies on risk markers of diabetes are ambiguous. This study was carried out to determine the effect of CLA supplementation (as 50:50 proportions of c9, t11 and t10, c12 CLA isomers) on serum lipid profiles, MDA, apo-B100, systolic and diastolic blood pressures in patients with T2DM. <u>Materials and Methods</u>: The study was a randomized double-blind, placebo-controlled parallel intervention. Participants were 39 T2DM patients (35 to 50 y, 30>BMI >25) stratified, according to sex, age and BMI into two groups. The intervention group took 3.0 g CLA/d (3×1g, capsules), a 50:50 isomer blend of c9, t11 and t10, c12 CLA) while the control group took soy bean oil as CLA placebo for 8 weeks. Blood pressure, serum lipid profile, MDA, and <place w:st="on">Apo</place> B were measured at baseline and at the end of the intervention. <u>Results</u>: There were no significant differences in serum triacylglycerol, total cholesterol, LDL-C, HDL-C, apo-B100 and MDA between the two groups after week 8 nor were any significant differences observed in systolic and diastolic blood pressure between the two groups after intervention. <u>Conclusion</u>: Results of this study suggest that short term CLA supplementation (3g/d) may not improve lipid profiles, apo-B100 and MDA concentrations in T2DM patients. </font></strong></p> اسید لینولئیک مزدوج، دیابت نوع 2، آپو 100B، مالون‌دی‌آلدئید، فشار خون Conjugated Linoleic Acid, Vitamin E, Type 2 diabetes mellitus, Apo-B100, MDA, Blood pressure 377 383 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-4-96&slc_lang=fa&sid=1 Zh Shadman ژاله شادمان 4000319475328460011343 4000319475328460011343 No R Rastmanesh سیدرضا راست منش 4000319475328460011393 4000319475328460011393 No FA Taleban فروغ اعظم طالبان 4000319475328460011394 4000319475328460011394 No M Hedayati مهدی هدایتی hedayati@endocrine.ac.ir 4000319475328460011395 4000319475328460011395 Yes