fa ارتباط بین لپتین سرم با عوامل التهابی و استرس اکسیداتیو در زنان یائسه‌ی مبتلا به دیابت نوع 2 پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><font face="Arial"><strong>Abstract</strong></font></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Leptin, a hormone secreted by the adipocytes, has a role in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus (NIDDM). There are relationships between Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6) with Body Mass Index (BMI) and insulin resistance. Increased lipid peroxidation leads to produce MDA in diabetic people. It have been shown<span style="mso-spacerun: yes">  </span>that, there are relationships between leptin and TNF-α ,<span style="mso-spacerun: yes">  </span>IL-6, and MDA,showing that increased lipid peroxidation leads to MDA production in diabetics. This study investigates relationships between serum leptin concentration and inflammatory intermediate and oxidative stress in postmenopausal diabetic women. <u>Materials and Methods</u>: We studied 45 postmenopausal diabetic women and 45 postmenopausal healthy women (controls), aged between 45-60 y and with BMI 25-30 kg/m2. Fasting blood sugar, serum leptin, TNF-α, IL-6, and MDA were determined in postmenopausal diabetics and healthy women, and comparisons were performed using the t test in the diabetic and healthy groups. Pearson correlation was used to evaluate the relations among different variables in two groups. <u>Results</u>: There were non significant correlations between leptin and TNF-α (r=0.2) and IL-6 (r= -0.06)<span dir="rtl"></span></font><span dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Lotus mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> </span><font face="Arial">in postmenopausal diabetic women, and also between leptin and MDA (r= 0.04) in postmenopausal diabetic women. <u>Conclusion</u>: There were no significant relationships between serum leptin and TNF-α, IL-6, and MDA in postmenopausal diabetic women. It seems these relationships need to be further clarified in future studies with larger sample sizes.<span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Lotus mso-ansi-font-size: 9.0pt"><p></p></span></font></strong></p> لپتین، عوامل التهابی، استرس اکسیداتیو، دیابت نوع 2 Leptin, Inflammatory factprs, Oxidative stress, Type 2 diabetes mellitus 371 376 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-4-95&slc_lang=fa&sid=1 M Taghdir مریم تقدیر 4000319475328460011342 4000319475328460011342 No SA Djazayeri سیدابوالقاسم جزایری jazaiers@tums.ac.ir 4000319475328460011388 4000319475328460011388 Yes M Djalali محمود جلالی 4000319475328460011389 4000319475328460011389 No M Ashourpour مهکامه عاشورپور 4000319475328460011390 4000319475328460011390 No M Sepandi مجتبی سپندی 4000319475328460011391 4000319475328460011391 No A Rajab اسداله رجب 4000319475328460011392 4000319475328460011392 No Iranian Diabetes Society,Tehran,I.R.Iran انجمن دیابت ایران، تهران