fa تأثیر مصرف لوبیای سویا بر هموسیستئین، Lp (a) و لیپوپروتئین‌های سرم زنان یائسه‌ی هیپرلیپیدمیک پژوهشی Original <span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><u>مقدمه</u></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA">: باتوجه به وضعیت نامطلوب لیپوپروتئین‌های سرم در زنان یائسه، این افراد در معرض بیماری‌های قلبی ـ عروقی هستند. پروتئین سویا احتمالاً باعث محافظت در برابر عوامل خطرساز این بیماری می‌گردد اگرچه اثرات آن بر هموسیستئین و </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> سرم متناقض است از طرفی تأثیر سویا در زنان یائسه هیپرلیپیدمیک تاکنون به طور مستقل مورد مطالعه قرار نگرفته است. هدف از این مطالعه برسی تأثیر مصرف سویا بر غلظت هموسیستئین، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> و لیپوپروتئین‌های سرم زنان یائسه هیپرلیپیدمیک بود. <u>مواد و روش‌ها</u>: در یک مطالعه‌ی کارآزمایی بالینی تصادفی 34 زن یائسه‌ی هیپرلیپیدمیک برحسب </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">BMI</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، تری‌گلیسرید </span><span dir="ltr"></span><span dir="ltr"></span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut"><span dir="ltr"></span><span dir="ltr"></span>(TG)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> و کلسترول تام </span><span dir="ltr"></span><span dir="ltr"></span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut"><span dir="ltr"></span><span dir="ltr"></span>(TC)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> سرم جور شده و به طور تصادفی به دو گروه مورد که 130 گرم لوبیا سویا حاوی 50 گرم پروتئین و 9/159 میلی‌گرم ایزوفلاوین مصرف می‌کردند شاهد که رژیم معمولی خود را ادامه می‌دادند (به مدت 10 هفته) تقسیم شدند. مقادیر سرمی لیپوپروتئین‌ها، هموسیستئین و </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> در شروع مطالعه و پایان هفته‌ی دهم اندازه‌گیری شدند. <u>یافته‌ها</u>: کاهش معنی‌داری در غلظت </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">LDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TC</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">LDL-c/HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TG/HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TC/HLD-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> و </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> سرم در گروه مورد در مقایسه با گروه شاهد در پایان هفته‌ی دهم وجود داشت. در گروه مصرف‌کننده‌ی سویا در انتهای مطالعه در مقایسه با شروع مطالعه افزایش معنی‌داری در </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> و کاهش معنی‌دار در </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">LDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TC</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">LDL-c/HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TC/HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">TG/HDL-c</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA"><font face="Yagut"><font size="3"><span style="mso-spacerun: yes"> </span>و هموسیستئین وجود داشت. <u>نتیجه‌گیری</u></font><font size="3">: مصرف 130 گرم سویا به مدت ده هفته در زنان یائسه‌ی هیپرلیپیدمیک مفیدی بر لیپوپروتئین‌ها و </font></font></span></span><span style="FONT-SIZE: 10pt FONT-FAMILY: "Times New Roman" mso-fareast-font-family: SimSun mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA mso-bidi-font-size: 11.0pt mso-bidi-font-family: Yagut">Lp(a)</span><span dir="rtl"></span><span dir="rtl"></span><span dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Yagut mso-ansi-font-size: 10.0pt mso-ascii-font-family: 'Times New Roman' mso-fareast-font-family: SimSun mso-hansi-font-family: 'Times New Roman' mso-font-kerning: 16.0pt mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA"><font face="Yagut" size="3">سرم گذاشت و خطر بروز بیماری‌های قلبی ـ عروقی را در زنان یائسه‌ی هیپرلیپیدمیک دریافت‌کننده‌ی سویا نسبت به گروه شاهد کاهش داد.</font></span></span> <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial">Abstract</font></strong></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Because of undesirable serum lipoprotein profiles, postmenopausal women are at risk of cardiovascular disease. Soy protein may help protect against these risk factors although its effect on homocysteine and Lp (a) is not clear however, the effects of soy bean in hyperlipidemic postmenopausal women has not been assessed independently yet. The aim of this study was to determine the effects of soy bean on serum concentration of homocysteine, Lp(a) and lipoproteins in hyperlipidemic postmenopausal women. <u>Material and Methods</u>: In a randomised clinical trial with parallel design, 34 hyperlipidemic postmenopausal women were randomly assigned to group 1 and given 130 g soy bean containing 50 g/d soy protein and 159/9mg isoflavones, while group 2 continued their usual diet for 10 weeks (controls). Serum lipoproteins, homocysteine and Lp (a) were measured at baseline and after the 10 th week. <u>Results</u>: There were significant decreases in Lp (a) LDL-c, TC, LDL-c/HDL-c, TG/HDL-c, TC/HDL-c in group 1, as compared to group 2, after ten weeks of study (p<0.05, p<0.001, p<0.01, p<0.01, p<0.05 and p<0.05 respectively) at the end of the study. Similarly, Lp(a), homocysteine, LDL-c, TC, LDL-c/HDL-c, TG/HDL-c, TC/HDL were significantly decreased ( p<0.01, p<0.05 p<0.01, p<0.01, p<0.01, p<0.05, p<0.01) at the end of the study, compared with initial values of the soy group. <u>Conclusion</u>: We can conclude that Soy protein reduces CVD risk in postmenopausal women because of both modest reductions in serum lipoproteins and Lp(a) in hyperlipidemic postmenopausal women.</font></strong></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt DIRECTION: ltr LINE-HEIGHT: 150% unicode-bidi: embed TEXT-ALIGN: justify"><span style="FONT-FAMILY: Tahoma mso-bidi-font-family: Yagut"><p><font size="2"> </font></p></span></p> سویا، زنان یائسه، لیپوپروتئین، هموسیستئین، کلسترول، تری‌گلیسرید Soy, Postmenopausal women, Lipoprotein, Homocysteine, Cholesterol, Triglyceride 345 352 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-81-68&slc_lang=fa&sid=1 F. Shidfar فرزاد شیدفر farzadshidfar@yahoo.com 400031947532846004082 400031947532846004082 Yes E. Ehrampoush الهام احرام پوش 400031947532846004083 400031947532846004083 No I. Heydari ایرج حیدری 400031947532846004084 400031947532846004084 No Sh Hosseyni شریعه حسینی 400031947532846004085 400031947532846004085 No SJ Hajimiresmail سیدجواد حاجی میراسماعیل 400031947532846004086 400031947532846004086 No MH Eftekhari محمدحسن افتخاری 400031947532846004087 400031947532846004087 No H. Mozaffari Khosravi حسن مظفری خسروی 400031947532846004088 400031947532846004088 No