fa اثر درمان با دهیدرواپی‌آندروسترون (DHEA) بر حساسیت انسولین در بیماران مبتلا به اختلال تحمل گلوکز پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial">Abstract</font></strong></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Dehydroepiandrostrone (DHEA) is one of three adrenal hormones and the most abundant estroid hormone in the body. Compared to other adrenal hormones, it decreases with advancing age, being 10-20% in the seventies, hence it is called the fountain of youth. Recently DHEA has been noticed for many of its effects including its antidepressant, protective effect on neuron injuries, effect on the hypocampaus and vascular endothelium, and its effects on autoimmune disease such as Lupus and ulcerative colitis there is however controversy regarding its effects on insulin sensitivity. <u>Material and Methods</u>: Based on glucose tolerance tests, subjects were selected from among patients, attending the <place w:st="on"><city w:st="on">Isfahan</city></place> endocrine research center 30 IGT patients by cross-over were treated with DHEA or placebo for six months and insulin sensitivity at the beginning and the end of treatment were compared. <u>Results</u>: In the first three months, the mean changes in the drug group were: DHEA-S 94μg/dL (P-value0.008), HOMA-IR 0.62 (P-value 0.6), insulin 1 μIU/mL (P-value0.3), FBS 10.5 mg/dL (P-value 0.1) and changes in placebo group were: DHEA-S 2.5 (P-value 0.6), HOMA-IR 0.9 (P-value 0.03), FBS 15.5 (P-value 0.1), insulin 3.5 (P-value 0.05). In the second three months, the mean changes in the drug group were: DHEA-S 166 μg/dL, FBS 4.6 mg/dL, insulin 0.6 μIU/mL, HOMA-IR 0.2, while changes in the placebo group were: DHEA-S 25, FBS 5.8, insulin 1.5, HOMA-IR 0.6. <u>Conclusion</u>: This study showed that the treatment with DHEA did not improve insulin sensitivity, but probably is effective in preventing increase in insulin resistance. <span lang="FA" dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Lotus mso-ansi-font-size: 9.0pt"><p></p></span></font></strong></p><p class="keyword" style="MARGIN: 0cm 0cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: center"><span style="mso-bidi-font-style: italic"><p><strong><font face="Book Antiqua" size="2"> </font></strong></p></span></p> DHEA، DHEA-S، حساسیت انسولین، تحمل قند DHEA،DHEA-S ,Glucose tolerance, Insulin sensitivity 339 344 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-81-67&slc_lang=fa&sid=1 A. Talaei افسانه طلایی afsanehtalaei@yahoo.com 400031947532846004070 400031947532846004070 Yes M. Amini مسعود امینی 400031947532846004071 400031947532846004071 No M. Siavash منصور سیاوش 400031947532846004072 400031947532846004072 No M. Zare مریم زارع 400031947532846004073 400031947532846004073 No