fa اثر 12 هفته اصلاح فعالیت‏های بدنی در زندگی، بر میزان کلسترول LDL- اکسید شده‌ی سرم در مردان چاق ورزش Exercise پژوهشی Original <p style="LINE-HEIGHT: 17pt TEXT-INDENT: 0cm MARGIN: 0cm 1cm 0pt mso-line-height-rule: exactly" dir="rtl" class="Abstract"><strong><span style="FONT-FAMILY: Lotus FONT-SIZE: 13pt mso-ansi-language: AF" lang="FA">چکیده</span><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-ansi-language: AF" lang="FA"><p></p></span></strong></p><p style="LINE-HEIGHT: 16pt TEXT-INDENT: 3.7pt MARGIN: 0cm 36pt 0pt 1cm mso-line-height-rule: exactly" dir="rtl" class="Abstract"><strong><u><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA">مقدمه</span></u><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA">: فعالیت ورزشی در جلوگیری از پیشرفت گرفتگی شریان‌ها موثر است، و کلسترول </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LDL-</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> اکسید شده (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ox-LDL-c</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>)، عمل آتروژنیکی مونوسیت‏ها را تسهیل می‏نماید. اثر آموزش اصلاح فعالیت‏های بدنی در زندگی (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>)، براساس دستورالعمل مراکز کنترل بیماری (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">CDC</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>) و کالج آمریکایی طب ورزش (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ACSM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>)، بر </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ox-LDL-c</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> سرم در افراد چاق به خوبی مشخص نیست. پژوهش حاضر به بررسی اثر 12 هفته </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt"><span dir="rtl"></span> <span lang="FA"><font size="3" face="Lotus">بر </font></span></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ox-LDL-c</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> سرم مردان چاق میان‌سال پرداخته است. <u>مواد و روش‌ها</u>: 16 مرد میان‌سال سالم چاق (میانگین و انحراف معیار سن 01/6±06/42 سال) به دو گروه شاهد (8=تعداد) و </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> (8=تعداد) تقسیم شدند. افراد گروه </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt"><span dir="rtl"></span> <span lang="FA"><font size="3" face="Lotus">براساس دستورالعمل </font></span></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">CDC</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> و </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ACSM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>، 4 روز در هفته و روزانه 2 مایل را در مدت طی 30 دقیقه روی نوارگردان، برای 12 هفته پیاده‌روی نمودند. <u>یافته‌ها</u>: یافته‌ها نشان داد وزن بدن، نمایه‌ی توده‌ی بدن، توده‌ی چربی، درصد چربی، نسبت دور کمر به لگن و مقدار کلسترول </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LDL-</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> پس از 12 هفته تمرین </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> نسبت به گروه شاهد کاهش معنی‌داری داشت (05/0></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">P</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>). هم‌چنین، بیشینه‌ی اکسیژن مصرفی پس از 12 هفته تمرین </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> نسبت به گروه شاهد افزایش معنی‏داری را نشان داد (05/0></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">P</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>). از سوی دیگر، پس از 12 هفته تمرین </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> اختلاف معنی‌داری در سطح کلسترول </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ox-LDL-</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> ، کلسترول تام (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">TC</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>)، تری‏گلیسرید (</span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">TG</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span>) و کلسترول ـ </span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">HDL</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt"><span dir="rtl"></span> <span lang="FA"><font size="3" face="Lotus">بین دو گروه مشاهده نشد. <u>نتیجه‏گیری</u>: هر چند 12 هفته تمرین </font></span></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LAM</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt"><span dir="rtl"></span> <span lang="FA"><font size="3" face="Lotus">موجب بهبود ترکیب بدن، آمادگی قلبی ـ تنفسی و کاهش سطح کلسترول</font></span></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">LDL-</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt"><span dir="rtl"></span> <span lang="FA"><font size="3" face="Lotus">در مردان چاق ‌میان‌سال گردید، اما این نوع روش تمرینی بر مقدار </font></span></span><font face="Arial"><span style="mso-font-kerning: 16.0pt" dir="ltr">ox-LDL-c</span><span dir="rtl"></span></font><span style="FONT-FAMILY: Lotus FONT-SIZE: 11pt mso-ansi-font-size: 9.0pt mso-font-kerning: 16.0pt" lang="FA"><span dir="rtl"></span> سرم مردان چاق ‌میان‌سال تاثیری نداشت.<p></p></span></strong></p> Abstract Introduction: Exercise significantly prevents the progression of atherosclerosis and oxidized LDL-C (ox-LDL-C), facilitates monocyte-related atherogenesis. The effects of Lifestyle Activity Modification (LAM) training based on guidelines of the Centers for Disease Control (CDC) and the American College of Sports Medicine (ACSM) on serum oxidized LDL-C (ox-LDL-C) in obese people are not well known. We investigated the effect of LAM on serum ox-LDL-C in obese middle aged men. Materials and Methods: Sixteen healthy obese middle aged men (aged 42.06±6.01 years, mean ± SD) were randomly assigned to the LAM (n=8) and the control (n=8) groups. Subjects in the LAM group walked 2 miles daily in 30 minutes 4 days weekly for 12 weeks on treadmills, according to the CDC and ACSM guidelines. Results: Results showed that body weight, BMI, body fat mass, body fat percent, waist to hip ratio (WHR) and LDL-C decreased significantly after 12 weeks in the LAM group compared to the controls (P<0.05), and their maximum oxygen uptake was increased significantly compared to the controls after 12 weeks (P<0.05). On the other hand, after 12 weeks of LAM training, no significant differences were observed in serum ox-LDL-C, total cholesterol (TC), triglycerides (TG) and HDL-C between the groups. Conclusion: Although twelve weeks of LAM improved body composition and cardio-respiratory fitness and decreased LDL-C levels in obese middle aged men, serum ox-LDL-C were not affected by this protocol in this group. LAM، LDL-c اکسید شده، چربی خون، مردان چاق LAM, Oxidized LDL-C, Blood lipid, Obese men 486 492 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-569-5&slc_lang=fa&sid=1 Mehrzad Moghadasi مهرزاد مقدسی moghadasi39@yahoo.com 4000319475328460015843 4000319475328460015843 Yes Islamic azad university, shiraz branch دانشگاه آزاد اسلامی شیراز Hamid Mohebbi حمید محبی mohebbi_h@yahoo.com 4000319475328460015844 4000319475328460015844 No Guilan university دانشگاه گیلان Mohadeseh alsadat Nematollah zadeh mahani محدثه السادات نعمت الله زاده ماهانی nematollahzadeh@gmail.com 4000319475328460015845 4000319475328460015845 No Islamic Azad University, Fars Science & Research branch, Iran دانشگاه آزاد واحد علوم و تحقیقات فارس