:: Volume 2, Issue 2 (6-2000) ::
2000, 2(2): 99-105 Back to browse issues page
Comparison of iodized oil injection and suppressive doses of thyroid hormones on bone mineral density (BMD)
H Bazrafshan , Y Mehrabi, F Azizi
Abstract:   (25845 Views)
Abstract: In order to determine bone mineral density (BMD) in patients with simple goiter who were treated with either thyroid hormone (levothyroxine) or injection of iodized oil solution, 68 goiterous patients aged 51±6 (mean ± SD) were studied. 51 patients who had received suppressive doses of levothyroxine for 61±29 months (mean ± SD) were randomly allocated into three groups group I included 18 patients who were treated with one milliliter of iodized oil solution without receiving thyroxine group II, included 18 patients in whom treatment with suppressive doses of levothyroxine was continued, and group III included 15 patients who didn’t receive any treatment. The fourth group consisted of 17 controls who had never been treated with levothyroxine before. In groups I to IV the number of menopausal patients were 13, 13, 9, and 12 respectively. Serum T3, T4, TSH, T3RU, calcium, and phosphorus levels and urine calcium level were measured. BMD was determined in L2-L4 vertebrae, femoral neck (FN), femoral ward (FW) and femoral trochanter (FT) using lunar DPXL device (with DEXA method), approximately 6 months after the intervention. Serum T3, T4, T3RU, Calcium and phosphorus levels and urine calcium level were not significantly different among the groups. Serum TSH in group II was significantly lower than the other groups (P<0.004). BMD results showed no significant difference among the groups (for example BMD results in L2-L4 region in groups I to IV were 1.03±0.98, 1.1±0.32, 1±0.15, and 1.30±0.11, respectively). In all groups positive correlations were observed between the length of the menopause and reduction in BMD. There was no significant difference between BMD results in pre-menopausal and post-menopausal women in L2-L4 (1.09±0.19 vs 1.05±0.16), femoral neck (0.89±0.14 vs 0.85±0.17), femoral trochanter (0.73±0.12 vs 0.68±0.10), but BMD in femoral ward was significantly less in post-menopausal women compared with pre-menopausal subjects (0.65±0.12 vs 0.74±0.13 P<0.005). This study shows that administrating suppressive doses of levothyroxine and injecting iodized oil don’t reduce bone mineral density in pre and post-menopausal women 6 months after the intervention.
Keywords: Bone mineral density, Iodized oil, Levothyroxine, Goiter
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Type of Study: Original | Subject: Endocrinology
Received: 2006/11/14 | Published: 2000/06/15

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