[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 22, Issue 2 (11-2020) ::
2020, 22(2): 137-150 Back to browse issues page
Comparison of the Effects of Desoceptive and Etisterone Pills on the Clinical, Hormonal, and Metabolic Findings of Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial
Mina Amiri Dr. , Razieh Bidhendi-Yarandi Dr. , Fatemeh Nahidi Dr. , Fahimeh Ramezani Tehrani Dr.
Shahid Beheshti University of Medical Sciences
Abstract:   (1951 Views)
Introduction: Oral contraceptives (OCs) have been recommended as the first-line drug therapy for polycystic ovary syndrome (PCOS). This study aimed to compare the effectiveness of Desoceptive and Etisterone OCs on the clinical, hormonal, and metabolic parameters of patients with PCOS over six months. Materials and Methods: In this randomized clinical trial, 200 patients with PCOS were randomly assigned to one of the intervention groups: Desoceptive (ethinyl estradiol+desogestrel) and Etisterone (ethinyl estradiol+cyproterone acetate). The outcomes of interest included the androgenic profile, Ferriman-Gallwey score, and anthropometric and metabolic parameters. Results: After 3-6 months of treatment with OCs, there were no significant differences in the levels of androgens, including the free androgen index, sex hormone-binding globulin, total testosterone, and dehydroepiandrosterone sulfate between patients treated with Desoceptive and Etisterone. The results also showed no significant differences between the two groups in terms of the Ferriman-Gallwey score and anthropometric parameters. After 3-6 months of treatment, patients treated with Desoceptive had lower serum triglyceride levels than those treated with Etisterone (regression coefficient: -32.3; 95% CI: -56.4, -8.2; P=0.009 and regression coefficient: -33.5; 95% CI: -57.6, -9.4; P=0.006, respectively). Moreover, the results showed that three months after treatment, patients treated with Desoceptive had higher levels of low-density lipoprotein (LDL) than those treated with Etisterone (regression coefficient: 12.3; 95% CI: 0.5, 24.1; P=0.040), while after six months of treatment, the LDL level was not significantly different between the two groups. Conclusion: Based on the present findings, use of OCs, containing anti-androgenic and androgenic progestins for 3-6 months, did not significantly change the hormonal profile or anthropometric and hirsutism parameters. OCs containing Desogestrel were associated with a more significant decrease in the triglyceride level, while OCs containing cyproterone acetate were associated with a more significant increase in LDL.
Keywords: Oral contraceptives (OCs), Polycystic ovary syndrome (PCOS), Hyperandrogenism, Metabolic profile
Full-Text [PDF 1590 kb]   (184 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2020/04/18 | Accepted: 2020/10/13 | Published: 2020/11/30
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amiri M, Bidhendi-Yarandi R, Nahidi F, Ramezani Tehrani F. Comparison of the Effects of Desoceptive and Etisterone Pills on the Clinical, Hormonal, and Metabolic Findings of Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial. Iranian Journal of Endocrinology and Metabolism. 2020; 22 (2) :137-150
URL: http://ijem.sbmu.ac.ir/article-1-2724-en.html


Volume 22, Issue 2 (11-2020) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.04 seconds with 31 queries by YEKTAWEB 4311