Introduction: Diabetes is a common metabolic disorder associated with an increased risk of cardiovascular disease, disability, and mortality. The present study was conducted to evaluate the effects of alcoholic extract of Ziziphora tenuior L (ziziphora) plant on blood glucose and fat profiles in streptozotocin-induced diabetic rats. Materials and Methods: In this study, 40 male wistar rats were divided into five groups: control, diabetic control, experimental group receiving dose 50, 75 and 100 mg/kg of hydoalcholic exctract of ziziphora. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg). After 28 days, the extract was gavaged, blood samples were collected and biochemical analysis was performed to determine the levels of glucose, insulin and lipid profiles in the serum. Results: The alcoholic extract of ziziphora consumed three in all doses significantly increased body weight, insulin and decreased blood glucose but did not have a significant effect on cholesterol, HDL and LDL. Conclusion: Oral administration of the hydroalcholic extract of the ziziphora probably leads to a decrease in blood glucose in type 1 diabetic rats by increasing insulin secretion.