Introduction: Type 1 diabetes is one of the most common of chronic metabolic disturbances in the adolescent period. This disease is often considered as a family disease because its management needs and support of family members, considering the nature of diabetes and the need for self-care in patients, the family-centered empowerment model of with emphasis on the effective role of the individual and family members in three-dimensions of prevocational, psychological and properties of the problem can be a suitable frame for instructional intervention. Therefore, this study aimed to determine the effects of the empowerment model of family-centered intervention on the quality of life and self-efficacy of adolescents with diabetes. Materials and Methods: This is quasi-experimental study of 100 adolescents with type 1 diabetes, have divided  randomly in two groups (n=50 each) of intervention and controls. Family-centered empoverment model intervention with four dimensions of perceived threat, self-efficacy, instructional partnership and evaluation was done in 5 sessions in the intervention group. Data of the patient’s demographic profile, questionnaire of standard scale self-efficacy in the management of diabetes and the quality of life of questionnaire for adolescents with diabetes were collected before, after immediately, and 1.5 months and 3 months after of intervention. For analysis of data, we used SPSS software version 21 and statistical test, K-square, paired and independent T and analysis of variance of duplicate sizes. Results: Results showed that after implementation of empowerment pattern of family-centered increased mean of the self-efficacy scores and quality of life at 1.5 months and 3 months after intervention in the intervention group a difference that was meaningful in terms of statistical significance (p<0.001). Conclusion: Study results showed that diabetes education with the patient empowerment approach which performed at the family level can improve patients self-efficacy and increase quality of life adolescences with diabetes, and can be implemented by nurses to assist the family and patient in medical care.