[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
:: Volume 4, Issue 4 (12-2002) ::
2002, 4(4): 213-216 Back to browse issues page
Effect of chloroquine on diabetes control in type 2 diabetic patients
M Mohammady , M Amini, T Ghafghazi
, emrc@mui.ac.ir
Abstract:   (27025 Views)
Introduction: As the control of diabetes is important, finding the ways which facilitates patient’s, treatment is the major aim for this research. Chloroquine was considered for diabetes treatment because of its hypoglycemic effects. This study was conducted to detect the effect of chloroquine on diabetes control in type 2 diabetic patients. Material and Methods: In a clinical trial, type 2 diabetic patients referred to Isfahan Endocrine and Metabolism Research Center during the year of 1999-2001 who had inclusion criteria using a convenience sampling method were selected. Selected patients were type 2 diabetic patients under treatment with oral antidiabetic agents, in whom the disease had not been controlled, and so were candidates for insulin therapy. In this group, beside other drugs, one tablet of chloroquine was recommended for two months. Weight, blood pressure, fasting blood glucose (FBS), glycosylated hemoglobin (HbA1c) and other laboratory tests were checked before and after 2 months administration of the drugs and the corresponding values were compared. Results: Mean FBS, HbA1c and BS2hpp were decreased significantly (FBS1= 183.07±65.12, FBS2 = 131.92±26.59, P<0.05), HbA1c1 = 10.36±2.05, HbA1C2 = 8.36±1.32, P<0.05), (BS2hpp1 = 254.7±104.2, BS2hpp2 = 195.54±59.8, P<0.05). Other variables did not change significantly. Conclusion: Results of this study show that chloroquine decreases did serum glucose level in type 2 diabetic patients who are resistant to oral anti-diabetic agents. This effect is due to role of chloroquine in decreasing degradation, thus increased glucose exposure to cells.
Keywords: Chloroquine, Diabetes mellitus (type 2), Control
Full-Text [PDF 272 kb]   (8426 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2006/11/22 | Published: 2002/12/15
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mohammady M, Amini M, Ghafghazi T. Effect of chloroquine on diabetes control in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism. 2002; 4 (4) :213-216
URL: http://ijem.sbmu.ac.ir/article-1-205-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 4 (12-2002) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4410