Introduction: The direct relationship between inflammation and resistance to insulin has been well codumented. It also has been demonstrated that the aim of this study was to evaluate the effect of eight weeks aerobic interval training on adiponectin serum levels, lipid profiles and HS-CRP in women with type II diabetes. Materials and Methods: In this study, 18 patients with type II diabetes were  enrolled in two groups (experimental and control). The experimental group underwent aerobic interval training and pedaling on the ergometer bicycle with 65 to 80 percent of their maximum leg power, three times a week for eight weeks. Blood samples were obtained in two pre-test and post-test steps to measure the adiponectin serum levels and HS-CRP by the ELISA method and lipid profiles using biochemical methods. Results: Statistical analysis showed that after eight weeks of aerobic interval training, adiponectin serum levels, lipid profiles and HS-CRP of the experimental group showed no significant differences in comparison with the controls (p>0.05). Conclusion: Results indicate that in women with type II diabetes, aerobic interval training, three times a week, for eight weeks with 65 to 80 percent of maximum leg power, improves resistance to insulin but, has no effect on adiponectin serum levels, lipid profiles and HS-CRP.