:: Volume 6, Issue 1 (3-2004) ::
2004, 6(1): 13-19 Back to browse issues page
High prevalence of congenital hypothyroidism in Isfahan, Iran
M Hashemipour, M Amini, R Iranpour, A Javadi, GH Sadri, N Javaheri, G Sattari, S Haghighi, S Hovsepian
, emrc@mui.ac.ir
Abstract:   (28684 Views)
Introduction: Hypothyroidism is one of the preventable causes of mental retardation, which according to its clinical manifestations within the neonatal period, can be diagnosed in only fewer than 10% of cases. Delayed diagnosis results in irreversible cerebro-auditory complications unless the problem is diagnosed by screening programs. Materials and Methods: From May to December 2002, T4 and TSH concentrations of 20,000 serum samples obtained from newborns on 3rd-7th day of birth, born in seventeen hospitals throughout Isfahan were measured by RIA and IRMA, respectively. The newborns with abnormal screening results (TSH> 20 mIU/L, T4<6.5 μg/dL and based on the weight) were re-examined. Newborns with TSH >10mIU/L and T4<6.5 μg/dL on the second measurement were considered to be hypothyroid so treatment was begun. After performing complementary tests, the hypothyroid patients received replacement therapy with levothyroxine. Results: From 20,000 neonates that were examined, 531 were recalled (Recall rate = 2.65%) and 54 newborns were diagnosed as hypothyroid. The prevalence of neonatal hypothyroidism was estimated to be 1/370. Conclusion: Considering the high prevalence of the disease in the population, the necessity of routine neonatal screening programs is underscored.
Keywords: Congenital hypothyroidism, Screening, T4, TSH
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Type of Study: Original | Subject: Endocrinology
Received: 2006/11/20 | Published: 2004/03/15

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Volume 6, Issue 1 (3-2004) Back to browse issues page