:: Volume 15, Issue 5 (2-2014) ::
2014, 15(5): 463-469 Back to browse issues page
Association of Vitamin D and Cognitive Disorders an Older Population of Amirkola
Alijan Ahmadi ahangar , Seyedreza Hosseini , Farzan Kheirkhah , Naghmeh Nabizadeh , Ali Bijani
Babol University of Medical Sciences , hosseinim46@yahoo.com
Abstract:   (8308 Views)

Introduction: Vitamin D receptors are widespread in brain tissue, and the active form of vitamin D has been documented for its neuroprotective effects. This study was conducted to determine the association between vitamin D level and cognitive disorders. Materials and Methods: This descriptive–analytical cross sectional study was conducted within the framework of the "Amikola Health and Aging Project (AHAP)", (2011-12), conducted on 1616 older people, aged>60 years in the city of Amirkola, Iran. Serum levels of vitamin D were measured in morning blood samples and mental status was investigated using Mini-Mental State Examination (MMSE). Data was analyzed with T test, ANOVA and Chi-square, and P-values <0.05 were considered signif­icant. Results: The mean age of study participants was 68.81±7.1 years. Among them 509 (31.5%) had cognitive impairment and 1103 (68.4%) did not. There was significant association between serum vitamin D level and normal and abnormal MMSE in women (P=0.029), but not in men (P=0.49). Mean serum vitamin D level in participants with normal MMSE was 34.45±32.79 ng/ml and in participants with abnormal MMSE was 32.80±29.39 ng/ml but this finding was not significant (P=0.31). Conclusions: Serum vitamin D level in older persons with normal MMSE was higher than in those with abnormal MMSE, although it was not significant. In this study, there was no association between serum vitamin D levels in older people with or without cognitive impairment.

Keywords: Cognitive disorder, Vitamin D, Elderly
Full-Text [PDF 327 kb]   (3535 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2012/11/25 | Accepted: 2013/07/6 | Published: 2014/01/29


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Volume 15, Issue 5 (2-2014) Back to browse issues page