fa مقایسه‌ی سطح سرمی لپتین افراد چاق دیابتی با افراد چاق غیردیابتی و ارتباط آن با شاخص‌های تن‌سنجی پژوهشی Original <p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><font face="Arial"><strong>Abstract</strong></font></p><p class="Abstract" style="MARGIN: 0cm 1cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: justify"><strong><font face="Arial"><u>Introduction</u>: Leptin, the product of the ob gene, plays a significant role in the pathogenesis of obesity and type 2 diabetes mellitus. The aim of this study was to compare serum leptin level in non-diabetic and type 2 diabetic obese subjects and assess its relationship to anthropometric indices. <u>Material and Methods</u>: This cross-sectional study was performed on 35 obese subjects with type 2 diabetes and 35 non-obese, non-diabetics. Fasting lipid profiles were measured using enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c. Serum leptin, insulin and glucose levels were measured by an enzyme immunoassay, using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated by homeostasis model assessment (HOMA-IR). <u>Results</u>: The mean<span dir="rtl"></span></font><span dir="rtl" style="FONT-SIZE: 11pt FONT-FAMILY: Lotus mso-ansi-font-size: 9.0pt"><span dir="rtl"></span> </span><font face="Arial">of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than in non-diabetic subjects (P < 0.05). Serum leptin levels were significantly lower in diabetics than in non-diabetics (21.51±2.18 vs. 30.36±2.46) and were significantly higher in women than in men (31.85±17.96 vs.12.80±9.02) in the diabetic and (36.11±10.99 vs. 23.55±15.72) in non-diabetic groups. There was a direct and significant correlation between serum leptin levels with hip circumference (r= 0.450, p= 0.04) in diabetics and (r=0.590, p=0.000) in non-diabetics, and between leptin and BMI (r= 0.666, p= 0.000) in diabetic and (r= 0.490, p= 0.003) in non-diabetic groups. <u>Conclusion</u>: Since the mean serum leptin level is lower in obese diabetes, compared to non-diabetics, further studies are required to clarify the mechanisms of lower leptin levels in obese diabetic subjects.</font></strong></p> دیابت نوع 2، چاقی، لپتین، نمایه‌ی توده‌ی بدن (BMI) Type 2 diabetes, Obesity, Leptin, BMI 353 362 http://ijem.sbmu.ac.ir/browse.php?a_code=A-10-81-69&slc_lang=fa&sid=1 Gh Mohamadzadeh قربان محمدزاده 400031947532846004089 400031947532846004089 No N Zarghami نصرت اله ضرغامی zarghami@tbzmed.ac.ir 400031947532846004090 400031947532846004090 Yes S. Zahedi Asl صالح زاهدی اصل 400031947532846004091 400031947532846004091 No