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Correlation between dehydroepiandrosterone sulfate (DHEA-S) & coronary artery disease.
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B Aminian   , MA Ostovan , GH Omrani |
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Abstract: (37594 Views) |
| Abstract: Dehydroepiandrosterone (DHEA) or its sulfate derivative (DHEA-S) is the major C19 steroid hormone secreted by adrenal cortex. It has been claimed that it has an inverse correlation with atherogenesis through its antiproliferative effect. But this correlation is a matter of controversy. The aim of this study was to examine the effect of DHEA-S on coronary artery disease (CAD). In a prospective randomized study, 202 patients with possible CAD who underwent coronary angiography between January 1999 and June 1999 were studied. They were allocated into two groups, group 1 (n=142 Female: 39, Male: 103) had more than 75 percent cross-sectional area narrowing of at least one coronary artery, and group 2 (n=60 Female: 28,Male: 32) had no coronary artery disease. The age range was 18-75 years, and it was matched between the two groups. Level of DHEA-S (measured by two different methods ELISA and RIA), fasting blood sugar, full lipid profile (TG, total cholesterol, LDL-C, HDL-C) were measured in the two groups. Other major coronary risk factors were also compared between the two groups. The level of DHEA-S had an inverse linear correlation with age (r = -0.34 and P<0.01). There was no statistically significant correlation between the level of DHEA-S and coronary artery disease in different age groups in males and females. Likewise, there was no statistically significant correlation between the level of DHEA-S and blood sugar (P=0.08), HDL (P=0.41), LDL (P=0.09), body mass index (P=0.4), hypertension and current smoking. The present study doesn’t confirm the inverse correlation between DHEA-S and coronary artery disease. |
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| Keywords: Dehydroepiandrosterone sulfate, Coronary artery disease, Cholesterol, Myocardial infarction. |
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Full-Text [PDF 249 kb]
(5275 Downloads)
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Type of Study: Original |
Subject:
Endocrinology
Received: 2006/11/14 | Published: 2000/06/15
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