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:: Volume 12, Issue 6 (3-2011) ::
2011, 12(6): 580-587 Back to browse issues page
Allele Frequency of 12 Microsatellites in Chromosome 8, 11, 12 and 16 in Tehran Lipid and Glucose Study
Maryam sadat Daneshpour Dr, Massoud Houshmand Dr, Sirous Zeinali Dr, Mehdi Hedayati Dr, Maryam Zarkesh , Fereidoun Azizi Dr
, azizi@endocrine.ac.ir
Abstract:   (36925 Views)

Abstract

Introduction: Most linkage and population genetic studies that use microsatellites assume that the polymorphism observed at these loci is due simply to variation in the number of units of a single repeat. These variations guide us in the study of the genetic patterns of some disease. This study reports the allele frequency of 12 microsatellites in Tehranians. Materials and Methods: Five hundred and ninety-one subjects with an average age of 39±19 years, with and without metabolic syndrome, were selected for investigation of the allele frequency of 12 microsatellites, the D8S1132, D8S1779, D8S514, D8S1743, D11S1998, D11S1304, D11S934, D12S96, D12S1632, D12S329, D16S2624 and D16S3096 using and fragment analysis technique. Result: There are different repeats in the chromosomes studied. Chromosome 8: 10-26.2bp repeats chromosome 11: 8.1-35bp chromosome 12: 2-32bp and chromosome 16: 9.2-28bp. The most hetrozygote marker is D8S1132 and the least is D12S96. Conclusion: The most significant findings of this study is reporting allele frequency of some Short Tandem Repeats for the first time in Tehran. In this study some new alleles were found in Iranian subjects, the presence of which may be a tool for genetic association studies in the future.

Keywords: Allele, Microsatellite, Tehran Lipid and Glucose Study
Full-Text [PDF 267 kb]   (1971 Downloads)    
Type of Study: Original | Subject: Genetic
Received: 2009/10/17
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Daneshpour M S, Houshmand M, Zeinali S, Hedayati M, Zarkesh M, Azizi F. Allele Frequency of 12 Microsatellites in Chromosome 8, 11, 12 and 16 in Tehran Lipid and Glucose Study. Iranian Journal of Endocrinology and Metabolism. 2011; 12 (6) :580-587
URL: http://ijem.sbmu.ac.ir/article-1-796-en.html


Volume 12, Issue 6 (3-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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