:: Volume 12, Issue 2 (7-2010) ::
2010, 12(2): 177-180 Back to browse issues page
Allele Frequency of C-482T Polymorphism in Apolipoprotein CIII Gene in a Tehranian Population: Tehran Lipid and
Shahla Shojaei, Maryam alsadat Daneshpour, Sohrab Halalkhor, Fereidoun Azizi Dr, Mehdi Hedayati Dr
, hedayati@endocrine.ac.ir
Abstract:   (32406 Views)
Introduction: Apoc3, an apolipoprotein, is well known as a lipolysis inhibitor. It inhibits lipolysis by both HP and LPL activity inhibition and has been studied as a factor for hypertriglyceridemia for years. C-482T polymorphism in apoc3 gene promoter has associated with hypertriglyceridemia and insulin resistance, factors associated with the metabolic syndrome association factors. Materials & Methods: Subjects were randomly selected from the Tehran Lipid and Glucose Study. A 231 bp segment of the mentioned gene was amplified by PCR and the polymorphism revealed by RFLP using the MspI restriction enzyme. Results: Allele frequencies obtained for APOC3 -482C and -482T polymorphisms were 0.653 and 0.347 respectively. Genotype frequencies were in conformity with the Hardy-Weinberg expectation. Conclusion: The observed genotype and allele frequencies were similar to those reported for other Caucasians samples. The data generated from this study will be of importance in the context of ongoing studies concerning the factors that influence lipid levels in Iranian populations.
Keywords: Apolipoprotein C3, Polymorphism, Frequency
Full-Text [PDF 254 kb]   (1824 Downloads)    
Type of Study: Original | Subject: Cardiology
Received: 2008/12/21 | Accepted: 2014/05/24 | Published: 2014/05/24

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Volume 12, Issue 2 (7-2010) Back to browse issues page