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Association between CRP Gene Polymorphisms and Serum CRP Levels: Tehran Cardiometabolic Genetic Study (TCGS)
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Z Taheryan amiri    , A Zahedi , M Jahangiri , S Masjoodi , M Zarkesh , M Akbarzadeh , M Hedayati , F Azizi , MS Daneshpour |
| Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences, Tehran, Iran. , daneshpour@sbmu.ac.ir |
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Abstract: (1735 Views) |
Introduction: C-reactive protein (CRP) is an acute-phase protein produced by the liver in response to inflammation and is recognized as a key biomarker for inflammation. Elevated CRP levels in the blood indicate the onset of an inflammatory response in the body, which can result from various factors, including infection, tissue damage, and chronic inflammatory conditions. This study aims to investigate the association between single nucleotide polymorphisms rs1205 and rs3093068 in the CRP gene with serum CRP levels in the Tehran Cardiometabolic Genetic Study (TCGS) adult population. Materials and Methods: In this case-control study, 639 individuals from the Tehran Cardiometabolic Genetic Study, with a mean age of 48±16 years (range: 20-87), were selected. Genotyping was performed using the HumanOmniExpress-24-v1-0 chip. Statistical analysis was carried out using R software. Results: The genotype frequencies followed Hardy-Weinberg equilibrium. The frequency of the CC genotype for both studied polymorphisms was significantly higher in individuals with a body mass index (BMI) above normal. Additionally, this genotype was more frequent in individuals with CRP levels above the normal range (CRP≥3000 ng). Conclusion: This study's findings suggest an association between the genotypes of the rs1205 and rs3093068 polymorphisms in the CRP gene and elevated serum CRP levels in the Tehran population under investigation. |
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| Keywords: Acute phase inflammatory protein, rs1205, rs3093068, CRP |
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Full-Text [PDF 983 kb]
(847 Downloads)
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Type of Study: Original |
Subject:
Genetic
Received: 2024/06/30 | Accepted: 2024/09/18 | Published: 2024/02/29
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