Introduction: One of the important parameters in health-related planning for any community is to determine trends in disease incidence of that community. This study aims to use the joinpoint regression model to determine changes in mortality trends of diabetes in seven Asian countries. Materials and Methods: Diabetes mortality data for six Asian countries and Iran were collected respectively from the World Health Organization and the Iranian Ministry of Health. The data were analyzed using the joinpoint regression model. To estimate regression parameters, least squares and permutation test were applied. Analyses were performed in Joinpoint3. 4 software. Results: Mortality rate from diabetes during the years under study increased on an annual basis in Armenia, Iran, Bahrain, Russia, South Korea and Kazakhstan as much as 7.5%, 4.5%, 2.7%, 1.2%, 5%, 3.1%, respectively. In Singapore, it had a 3.8% annual decline. The mortality rate of diabetes in the seven Asian countries increased at rate of 3.2% from 1985 to 2010. Conclusion: Given the annual changes in the diabetes-associated mortality rate in Armenia, Iran and South Korea compased to the annual rate of the seven countries, it is suggested that these three countries develop programs for screening and controlling diabetes.