Introduction: Adipose tissue secretes different hormones, such as adiponectin, which regulates various biological functions. The purpose of this study was therefore to determine the effects of resistance training with different patterns on Leptin, Adiponectin, Testosterone and cortisol in sedentary men. Materials and Methods: forty untrained men, aged 23.8±2.66 years and weight 67.43±4.96kg, voluntarily participated for this study and were randomly assigned toone of the four groups:upper, lower, whole body (3 session per week for 8 weeks,5 sets trainingwith60-85%of one repetition maximum)and control (each group n=10). Blood samples (5cc) were taken from the subjects in three steps (pretest, week4 and the day after end of the eighth week). Results: Results using analysis of variance with repeated measures showed that in the upper limb, after 8 weeks, fat percentage was decreased up to(7.39%) and leptin decreased (64.02%), adiponectin(90.42%),and testosterone increase significantly (24.19%) (P=0.001) relative to pretest. In the lower body, fat percentage (7.39%) and leptin (56.95%) decreased (P=0.001), while, adiponectin (87.82%)(P<0.01), and testosterone (23.54%) significantly (P=0.001) increased relative to pretest. In whole body, body mass index (1.88%),muscle mass(2/24%) and adiponectin (91.56%) significantly increased (P=0.001). In the meantime, leptin (59.3%) after eight weeks and cortisol (19.17%) after 4 weeks of training significantly decreased [respectively (P=0.001) and (P=0.001)] relative to pretest. Conclusion: In the present study types of resistance training caused increase in adiponectin and decrease in leptin. There was also an increase in testosterone levels and decrease fat percent in the upper and lower body groups. Results of this study, it indicate that resistance training among in active people is also associated with changes in hormone levels and can prevent cardiovascular disease in this group.