Introduction: About 20-40% of people with diabetes experience varying levels of distress and general symptoms of anxiety and depression. This study aimed to evaluate the effects of mindfulness-based stress reduction group training on depression, anxiety, stress, self-confidence and hemoglobin A1c in young women with type 2 diabetes. Materials and Methods: In this pretest-posttest-control group design study, we used instruments such as demographic data and depression, anxiety and stress (DASS-21) and the Rosenberg self-confidence questionnaires. The study population included 60 patients with diabetes randomly divided into 2, the experimental and control groups. The experimental group received the mindfulness intervention with 8 sessions each 2.5 hours while the control group received no intervention. Following this, during the ninth, session both groups again completed the questionnaires. Results: Patients in experimental group reported lower levels intensity of anxiety, stress and HbA1C, but higher self-confidence in comparison to the controls after intervention (P<0.05), although differences in levels of the  depression variable between two groups was not significant. In addition, between HbA1c and all variables, (depression, stress, self-confidence) significant correlations were observed. Conclusion: Results suggest that depression, anxiety, stress and self- confidence are associated with HbA1C level and a mindfulness-based stress reduction program can be effective in reducing the psychological symptoms in these patients, leading to increased confidence and improved glycemic control in women with type 2 diabetes.