:: Volume 16, Issue 5 (1-2015) ::
2015, 16(5): 371-382 Back to browse issues page
Effects of Growth Hormone Replacement on Clinical, Radiologic and Laboratory Parameters Improvement in Children with Vitamin –D dependent Rickets) type-2)
Nosrat Ghaemi Dr, Saghi Elmi Dr , Samaneh Kuzegaran Dr, Reza Erfani sayyar Dr, Sam Elmi Dr
mashhad university of science , sam_e313@yahoo.com
Abstract:   (5877 Views)

Introduction: Rickets, which occurs during bone growth development, is a result of severe vitamin D deficiency, that has autosolamal subtypes, i.e. A- type 1- (VDDR-I), due to a defect of the 1-alfa-hydroxilase enzyme and B) type -2(VDDR-II), due to a mutation in the intracellular vitamin –D receptor (VDR), associated with some specific symptoms like alopecia (global head hair loss) and short stature. Diagnosis was established based on physical examination, laboratory findings and radiological examination. Case presentation: We report here 3 cases with vitamin D-dependent rickets, type-II, all members of the same family (2 sisters, aged 1.5, 5 years and their 5 year-old cousin) who had referred to the endocrine and metabolic center in the Imam–Reza hospital in Mashhad, presenting with limb deformities, wide wrist, seizures, disorder in dental growth, alopecia, and several bone fractures. Despite various treatments, they had not recovered. However it was notable that after receiving growth hormone therapy for growth failure, rickets symptoms improved dramatically in clinical, laboratory, and radiological parameters. Using growth hormone therapy to improve height, we observed improvements in the underlying disease of siblings with VDDR-type-II. Conclusion: Growth hormone therapy may be advisable to treat VDDR-type II symptoms.

Keywords: Vitamin –D dependent rickets, Growth hormone, Alopesia, Short stature
Full-Text [PDF 3843 kb]   (1255 Downloads)    
Type of Study: Case report | Subject: Endocrinology
Received: 2014/05/18 | Accepted: 2014/11/22 | Published: 2015/01/11

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Volume 16, Issue 5 (1-2015) Back to browse issues page