Introduction: Obesity, a major health problem worldwide, is also risk factor for some diseases. Several different reports published the prevalence of obesity in Iran, but so far no accurate estimate of the rate of obesity has been documented in women, with an emphasis on physical activity. This study determined the prevalence of obesity in women 30-50 years of Neyshabur, with emphasis on their physical activity. Materials and Methods: This 1390 descriptive analytic was cross-sectional study of 381 Neyshaburi women. In this study, two questionnaires  comprising 55 questions was used to collect information in five sections: Personal characteristics, socioeconomic, nutritional status, fertility, and demographics the other was the Baek habitual physical activity questionnaire. For analysis, we used descriptive statistics, ANOVA test and other different types of correlation coefficients. Results: Results showed that the prevalence of obesity was  30.4%, over weight  45.5% and abdominal obesity 93.2%. Furthermore, we found that the lower the age of menarche, the higher was the body mass index of women (P=0.005). Rating of physical activity incidence during work and exercise in lean women was higher than other groups. Conclusion: Considering the high prevalence of obesity in Neyshabur, health authorities and relevant agencies need to implement modifications in lifestyle, nutritional status and physical activity among women.