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:: Volume 12, Number 5 (2-2011) ::
2011, 12(5): 513-519 Back to browse issues page
Effect of Calcitriol on Glycemic and Lipid Control in Type 2 Diabetes
dr shokoufeh bonakdaran *, dr mozhgan Afkhami zadeh
assisstant professor medical university
Abstract:   (38919 Views)

Abstract

Introduction: Vitamin D deficiency is prevalent worldwide. Low 25 hydroxyvitamin D3 concentrations inversely associated with type 2 diabetes, metabolic syndrome and insulin resistance. The aim of this study was the evaluation of effects of oral 1, 25 (OH) 2D3( calcitriol)  treatments on glycemic control and lipid profiles in patients with type 2 diabetes. Methods and Materials: This was an interventional study, conducted in Ghaem Hospital, Mashhad, Iran on 58 type 2 diabetic patients. Patients underwent calcitriol treatment with 0.5 microgram per day for 8 weeks. In all cases, clinical parameters including weight, systolic and diastolic blood pressure and laboratory parameters including levels of fasting blood glucose, insulin, lipid profile, calcium, phosphorous, HbA1C and insulin resistance (HOMA-IR) were measured, before and after the treatment period. The two sets of results were then compared with one another. Results: Following treatment with calcitriol,  FBS, HbA1C, Cholesterol, triglycerides and insulin resistance decreased but the changes were not significant (p>0.05). LDL and diastolic blood pressure decreased significantly after treatment with calcitriol. (p=0.02 and 0.04 respectively). Conclusion: Supplementation with active form of vitamin D did not have a significant effect on glycemic control but may be effective in control of hyperlipidemia and blood pressure in type 2 diabetic patients, findings which need to be confirmed in large randomized trials

Keywords: Diabetes, Vitamin D, Calcitriol, Blood Pressure, Lipid, Insulin Resistance
Full-Text [PDF 285 kb]   (1771 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2010/07/11
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PMCID: 23302101


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bonakdaran S, Afkhami zadeh M. Effect of Calcitriol on Glycemic and Lipid Control in Type 2 Diabetes. Iranian Journal of Endocrinology and Metabolism. 2011; 12 (5) :513-519
URL: http://ijem.sbmu.ac.ir/article-1-993-en.html
Volume 12, Number 5 (2-2011) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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