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:: Volume 19, Issue 3 (9-2017) ::
2017, 19(3): 170-176 Back to browse issues page
Effects of High Intensity Interval Training and Moderate-Intensity Continuous Training on VEGF Gene Expression in Visceral and Subcutaneous Adipose Tissues of Male Wistar Rats
Sara Ghafari Homadini Miss, Mohammad Reza Asad Dr, Behzad Bazgir Dr, Mostafa Rahimi Dr *
Assistant professor , Mostafa.rahimi20@gmail.com
Abstract:   (553 Views)

Introduction: The purpose of present study was to investigate the effects of high intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial growth factor (VEGF) gene expression in visceral and subcutaneous adipose tissues in male Wistar rats. Materials and Methods: For this experimental study, 24 male Wistar rats (250±20 gram) were divided in to 4 groups (n=6 each) basal control (n=6), 8 week controls (n=6), MICT (n=6), and HIIT (n=6) groups. The training program was running on the 4 treadmill for 8 weeks/5 days per week. Intensity of the MICT protocol was 50-75% of VO2max, and the duration was approxinately 15 to 60 minutes, which progressively increased. The HIIT protocol was 4-8×1 min with 70-100% of VO2 max and 1 min recovery with 50-70% VO2max, for a total duration of 15 to 23 minutes. Adipose tissue samples were removed 48 hours after the last training session and VEGF gene expression was measured by Real-Time PCR methods. Results: Results indicated that both MICT and HIIT induced significant increase in subcutaneous VEGF gene expression (P≤0.05), whereas, no significant changes in visceral VEGF gene expression were observed after either training protocol (P≥0.05). Conclusion: Based on findings, the MICT protocol, HIIT exercise training in particular, has more effects on subcutaneous adipose tissue angiogenesis than on visceral adipose tissue. 

Keywords: Adipose tissue, Angiogenesis, Moderate-intensity continuous training, High intensity interval training, Vascular endothelial growth factor
Full-Text [PDF 342 kb]   (215 Downloads)    
Type of Study: Original | Subject: Exercise
Received: 2017/05/24 | Accepted: 2017/08/6 | Published: 2017/09/20
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Ghafari Homadini S, Asad M R, Bazgir B, Rahimi M. Effects of High Intensity Interval Training and Moderate-Intensity Continuous Training on VEGF Gene Expression in Visceral and Subcutaneous Adipose Tissues of Male Wistar Rats. Iranian Journal of Endocrinology and Metabolism. 2017; 19 (3) :170-176
URL: http://ijem.sbmu.ac.ir/article-1-2252-en.html
Volume 19, Issue 3 (9-2017) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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