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:: Volume 20, Issue 6 (3-2019) ::
2019, 20(6): 312-319 Back to browse issues page
Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats
Amirali Mothagi , Hedar Aghababa ِDr , Mostafa Heydari , Saeed Hosseini , Ali Zarei Dr , Reyhaneh Voghofi , Saeed Changizi-Ashtiyani Dr
Department of Physiology, Arak University of Medical Sciences, Arak, Iran , ashtiyani@yahoo.com
Abstract:   (1288 Views)

Introduction: Diabetes is a common metabolic disorder associated with an increased risk of cardiovascular disease, disability, and mortality. The present study was conducted to evaluate the effects of alcoholic extract of Ziziphora tenuior L (ziziphora) plant on blood glucose and fat profiles in streptozotocin-induced diabetic rats. Materials and Methods: In this study, 40 male wistar rats were divided into five groups: control, diabetic control, experimental group receiving dose 50, 75 and 100 mg/kg of hydoalcholic exctract of ziziphora. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg). After 28 days, the extract was gavaged, blood samples were collected and biochemical analysis was performed to determine the levels of glucose, insulin and lipid profiles in the serum. Results: The alcoholic extract of ziziphora consumed three in all doses significantly increased body weight, insulin and decreased blood glucose but did not have a significant effect on cholesterol, HDL and LDL. Conclusion: Oral administration of the hydroalcholic extract of the ziziphora probably leads to a decrease in blood glucose in type 1 diabetic rats by increasing insulin secretion.

Keywords: Diabetes, Ziziphora, Blood glucose, Blood lipids
Full-Text [PDF 1128 kb]   (354 Downloads)    
Type of Study: Original | Subject: Endocrinology
Received: 2018/07/2 | Accepted: 2019/02/12 | Published: 2019/04/22
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Mothagi A, Aghababa H, Heydari M, Hosseini S, Zarei A, Voghofi R et al . Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats. Iranian Journal of Endocrinology and Metabolism. 2019; 20 (6) :312-319
URL: http://ijem.sbmu.ac.ir/article-1-2446-en.html


Volume 20, Issue 6 (3-2019) Back to browse issues page
مجله ی غدد درون‌ریز و متابولیسم ایران، دو ماهنامه  پژوهشی مرکز تحقیقات غدد درون‌ریز و متابولیسم، Iranian Journal of Endocrinology and Metabolism
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